Birgid Langer

Responsible for:

• the organisation of the praktika in biochemistry
• the security of the genetic laboratory
• all things to do around the chair
• the BOGY program at our chair
• Frauenbeauftragte of the departement of chemistry

Research fields:

• molecular biotechnology and gene technology
• protein chemistry including protein expression and isolation

Research topics:

• Identification of the prosthetic group of phenylalanine-ammonia lyase (Prof. Rétey)
• Postulation of the new mechanismn of action of phenylalanine-ammonia lyase (Prof. Rétey)
• Investigations around the behaviour of histidase with substrates and inhibitors (Prof. Rétey)
• in progress: in vivo labelling of peptides and proteins with fluoro-amino acids to determine their structure and to study their function (Prof. Ulrich)

Publications:

Schuster B. and Rétey J. (1994)
Serine-202 is the putative precursor of the active site dehydroalanine of phenylalanine ammonia lyase
FEBS Letters 349, 252-254

Schuster B. and Rétey J. (1995)
The mechanism of action of phenylalanine ammonia-lyase: the role of prosthetic dehydroalanine
Proc. Natl. Acad. Sci. USA 92, 8433-8437

Langer B., Stark J., Langer M. and Rétey J. (1997)
Formation of the Michaelis complex without involvment of the prosthetic group dehydroalanine of histidine ammonia-lyase
Bioorg. Med. Chem. Letters 7, 1077-1082

Langer B., Röther D. and Rétey J. (1997)
The role of arginine 174 in the mechanism of action of phenylalanine ammonia-lyase
Biochemistry 36, 10867-10971

Langer B., Röther D. and Rétey J. (1997)
Arginine 174 is essential for catalysis by phenylalanine ammonia-lyase from P. crispum
Biological Chemistry 378, 114

Gloge A., Langer B., Rétey J. (1997)
Further insights into the mechanism of action of phenylalanine ammonia-lyase
Biological Chemistry 378, 114

Gloge A., Langer B., Poppe L. and Rétey J. (1998)
The behavior of substrate analogues and secondary deuterium isotope effects in the phenylalanine ammonia-lyase reaction
Arch. Biochem. Biophys. 359, 1-7

Langer B., Langer M. and Rétey J. (2001)
Methylidene-imidazolone (MIO) from histidine and phenylalanine ammonia-lyase
Adv. Protein Chem. 58, 175-214

Röther D., Poppe L., Viergutz S., Langer B. and Rétey J. (2001)
Characterisation of the active site of histidine ammonia-lyase from Pseudomonas putida
Eur. J. Biochem. 268, 6011-6019